Introduction: despite advances in pharmacotherapy of schizophrenia-spectrum disorders, a large percentage of persons with schizophrenia remain at least partially nonresponeased healthcare cost, and poor quality of life for affected individuals. Areas covered: this paperprises a review of recent research in drug … 58BKTLviPEcM Other studies which rigorously defined treatment refractory populations have not shown this rate of response. (Breier et al., 1999; Lindenmayer et al., 2002) Therefore, these results suggest 1200 mg/day of quetiapine appears to be safe, tolerable, and may improve symptomatology in some patients with treatment refractory schizophrenia. Larger ... o0Y0AU6PD963 Jan 20, 2014 · In the InterSept study, in which clozapine was found to be superior to olanzapine in preventing suicidal behaviors in patients with refractory and non-refractory schizophrenia or schizoaffective disorder, there was no relationship between treatment resistance, the severity of psychotic symptoms at baseline, the change in psychosis during ... VqVMvftWwVTv Apr 01, 2006 · TO THE EDITOR: Olanzapine, an atypical antipsychotic, has been found superior in efficacy to haloperidol for the treatment of schizophrenia, with fewer extrapyramidal side effects (1, 2).The current guidelines for olanzapine use in schizophrenic patients suggest a maximum dose of 20 mg/day; the safety of doses above this level have not yet been evaluated in clinical … IN1hCbSu9XKs
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